VENOUS THROMBOEMBOLISM PROPHYLAXIS: A EUROPEAN PERSPECTIVE
Keywords:
venous thromboembolism, pulmonary embolism, anticoagulantsAbstract
Actuality. Venous thromboembolism (VTE) is a major public health issue. It remains one of the main causes of mortality. In addition, anticoagulant treatment, although effective, may be a potential source of iatrogenic complications. Results. The article highlights the major issues preventing venous thromboembolism. Currently, everything about VTE guidelines refers to the excellent ACCP (American College of Chest Physicians) recommendations which are considered to be THE reference worldwide. The ESA has built a task-force including seven ESA specialists in this topic, and some representatives from major European societies on orthopedics, general surgery, gynecology and obstetrics, medical intensive care and hemostasis and thrombosis. This body of 14 people + the chair will define the different questions to be addressed to the large advisory group in charge of drafting the guidelines. The recommendations will deal with perioperative (pre-, per- and post-) VTE prophylaxis, including the intensive care unit. The GRADE method will be used for the grading. At the end of the process, it is expected that the different participating bodies will endorse the guidelines, which wil be published in different European journals and especially in the European Journal of Anaesthesiology.
References
Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition) / W. H. Geerts, D. Bergqvist, G. F. Pineo [et al.] // Chest. – 2008. – N 133 (6 Suppl). – P. 381–453.
Venous thromboembolism prevention in surgery and obstetrics: clinical practice guidelines / C. M. Samama, P. Albaladejo, D. Benhamou [et al.] // Eur J Anaesthesiol. – 2006. – N 23 (2). – P. 95–116.
Prevention of VTE in nonorthopedic surgical patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines / M. K. Gould, D. A. Garcia, S. M. Wren [et al.] // Chest. – 2012. – Vol. 141. – e227S–277S.
CLOTS (Clots in Legs Or sTockings after Stroke) Trial Collaboration: Effectiveness of thighlength graduated compression stockings to reduce the risk of deep vein thrombosis after stroke (CLOTS trial 1): a multicentre, randomised controlled trial // Lancet. – 2009. – N 373 (9679). – P. 1958–1965.
CLOTS (Clots in Legs Or sTockings after Stroke) Trial Collaboration: Effectiveness of intermittent pneumatic compression in reduction of risk of deep vein thrombosis in patients who have had a stroke (CLOTS 3): a multicentre randomised controlled trial // Lancet. – 2013. – N 382 (9891). – P. 516–524.
Regional anaesthesia and antithrombotic agents: recommendations of the European Society of Anaesthesiology/ W. Gogarten, E. Vandermeulen H. , Van Aken [et al.] // Eur J Anaesthesiol. – 2010. – N 27 (12). – P. 999–1015.
Prevention of VTE in Orthopedic Surgery Patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines / Falck-Ytter Y., Francis C. W., Johanson N. A. [et al.] // Chest. – 2012. – N 141 (2 suppl). – e278S–e325S.
Venous thromboembolism prophylaxis in patients undergoing abdominal or pelvic surgery for cancer — A real-world, prospective, observational French study: PRéOBS / C. M. Samama, L. Boubli, P. Coloby [et al.] // Thromb Res. – 2013.
Morange P.-E. Thrombosis in central obesity and metabolic syndrome: mechanisms and epidemiology / P.-E. Morange, M-C. Alessi // Thromb Haemost. – 2013. – N 110 (4). – P. 669–680.
Thrombosis Prophylaxis and Mortality Risk among Critically Ill Adults / C. M. Lilly, X. Liu, O. Badawi [et al.] // Chest. – 2014.
Mandatory contrast-enhanced venography to detect deep-vein thrombosis (DVT) in studies of DVT prophylaxis: upsides and downsides / J. Hirsh, J. S. Ginsberg, N. Chan [et al.] // Thromb Haemost. – 2014. – N 111 (1). – P. 10–13.
Benefit-to-harm ratio of thromboprophylaxis for patients undergoing major orthopaedic surgery. A systematic review / R. D. Hull, J. Liang, D. Bergqvist [et al.] // Thromb Haemost. – 2014. – N 111 (2). – P. 199–212.
Prevention of venous thromboembolism: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy / W. H. Geerts, G. F. Pineo, J. A. Heit [et al.] // Chest. – 2004. – N 126 (3 Suppl). – 338S–400S.