RECOMMENDATIONS OF THE THIRD CONGRESS OF THE AMERICAN SOCIETY OF REGIONAL ANESTHESIA REGARDING THE SYSTEMIC TOXICITY OF LOCAL ANESTHETICS
DOI:
https://doi.org/10.31379/2411.2616.12.2.11Keywords:
ASRA, local anesthetics systemic toxicity, lipid rescue, peripheral blocks, practical recommendationsAbstract
The following article outlines the changes made by the American Society of Regional Anesthesia and Pain Medicine regarding the 2010 practical recommendations on local anesthetics systemic toxicity (LAST). Particular attention is paid to issues of lipid rescue, the terms of the assessment to the signs of toxicity, the preventive role of ultrasound navigation, changes of the pattern of clinical manifestations and limited data on toxicity in local infiltrative anesthesia. In addition to this information, the article provides recommendations for the prevention, recognition and treatment of local anesthetics systemic toxicity.
References
The Third American Society of Regional Anesthesia and Pain Medicine Practice Advisory on Local Anesthetic Systemic Toxicity: Executive Summary 2017 / Joseph M. Neal et al. Regional Anesthesia and Pain Medicine. 2018. Vol. 43, № 2. Р. 113–123.
Local anesthetic-induced cardiac toxicity: a survey of contemporary practice strategies among academic anesthesiology departments / W. Corcoran et al. Anesth Analg. 2006. Vol. 103. P. 1322–1326.
Butterworth J. F. 4th. Models and mechanisms of local anesthetic cardiac toxicity: a review. Reg Anesth Pain Med. 2010. Vol. 35. P. 167–176.
Clinical presentation of local anesthetic systemic toxicity: a review of published cases, 1979 to 2009 / G. Di Gregorio et al. Reg Anesth Pain Med. 2010. Vol. 35. P. 181–187.
Mulroy M. F., Hejtmanek M. R. Prevention of local anesthetic systemic toxicity. Reg Anesth Pain Med. 2010. Vol. 35. P. 177–180.
Weinberg G. L. Treatment of local anesthetic systemic toxicity (LAST). Reg Anesth Pain Med. 2010. Vol. 35. P. 188–193.
Gitman M., Barrington M. J. Local anesthetic systemic toxicity: a review of recent case reports and registries. Reg Anesth Pain Med. 2018. Vol. 43. P. 124–130.
ACC/AHA guideline update for perioperative cardiovascular evaluation for noncardiac surgery: executive summary: a report of American College of Cardiology/American Heart Association ask Force on Practice Guidelines (Committee to Update the 1996 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery) / K. A. Eagle et al. J Am Coll Cardiol. 2002. Vol. 39. P. 542–553.
Multi-modal contributions to detoxification of acute pharmatoxicity by a triglyceride microemulsion / M. R. Fettiplace et al. J Control Release. 2015. Vol. 198. P. 62–70.