PREVENTION OF POSTOPERATIVE PAIN
DOI:
https://doi.org/10.31379/2411.2616.11.1.12Keywords:
pain, NDMA-receptors, premedicationAbstract
Patrick Wall in an Editorial of Pain in 1988 was extremely enthusiastic with the concept of pre-emptive analgesia, corresponding to the prevention of postoperative pain by analgesics used before surgery. In fact, the prevention of surgical pain is an old idea, already proposed by Crile in the Lancet in 1913, and many anaesthesiologists were utilising this principle giving morphine or pethidine in premedication. Many trials performed without adequate methodology brought contrasted results. Kissin in 1996, observed that the effects were not always obvious and the reality rather disappointing. Recently, several meta-analysis, based upon publications according to a correct methodology and introducing new drugs especially NDMA receptors inhibitors (dextrometorphan, ketamine) and inhibitors of voltage-dependant calcium channels (gabapentin, pregabalin) have opened new horizons.
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