THE HEMODIALYSIS INDUCED BLOOD GLUTAMATE REDUCTION IN CHRONIC RENAL FAILURE: POTENTIAL IMPLEMENTATION FOR NEUROPROTECTION
Keywords:
brain injury; glutamate; glutamate oxaloacetate transaminase (GOT); glutamate pyruvate transaminase (GPT); hemodialysisAbstract
Purpose. The purpose of the present study is to investigate whether hemodialysis (HD) may be effective in lowering blood glutamate levels. Additionally, we examined the effect of HD on glutamate oxaloacetate transaminase (GOT) and glutamate pyruvate transaminase (GPT) levels in the blood and describe the rate and pattern of blood glutamate clearance during HD. Material and methods. Blood samples were taken from 45 patients with stage V chronic kidney disease immediately after initiation of HD, and hourly for a total of 5 blood samples. Samples were sent for determination of glutamate, glucose, GOT, GPT, hemoglobin, hematocrit, urea and creatinine levels. A blood sample from 25 healthy volunteers without chronic renal failure was used as a control for the determination of baseline blood levels of glutamate, GOT and GPT. Results. Glutamate levels and GPT levels in patients on HD were higher at baseline compared with healthy controls (p<0.001). In the first 3 hours after HD, there was a decrease in blood glutamate levels compared with baseline levels (p<0.00001). At the 4th hour, there was an increase in blood glutamate levels compared with the 3rd hour (p<0.05). Conclusions. HD may be a promising method of reducing blood glutamate levels.
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