SOME ASPECTS OF THE PATHOGENESIS OF THE HEMOSTASIS SYSTEM

Authors

  • I. Savytskyi
  • L. Karabut
  • V. Savytskyi
  • T. Alexandrina

DOI:

https://doi.org/10.31379/2411.2616.18.2.6

Keywords:

hemocoagulation, platelets, coagulation factors, fibrinolysis

Abstract

The article considers the main modern theoretical concepts of the hemocoagulation system. Described in details not only the mechanisms of vascular-platelet and coagulation hemostasis, but also the main components of the anticoagulation system and fibrinolysis. Thus, the thrombogenesis system is a chain of complex cascade-complex enzymatic reactions that involve a many of cellular and humoral agents with subtle mechanisms of neuroendocrine regulation.

References

Mamaev A.N. Practical hemostasiology. – Moscow : Practical Medicine, 2014. – 240 p.

Recently identified factors that regulate hemostasis and thrombosis / J.E. Geddings, N. Mackman // Journal of Thrombosis and Haemostasis. – 2014. – Vol. 111. – № 4. – P. 570–574.

2014, Dynamics of pathological clot formation: a mathematic model / E.A. Shavlyugin, M.A. Khanin, L.G. Khanin // Journal of Theoretical Biology. – 2014. – Vol. 340. – № 24. – P. 96–104.

Modern presentation of the system of hemostasis / G.L. Volkov, T.N. Platonova, A.N. Savchuk. – Kyiv : Scientific thought, 2005. – 296 p.

The role of endothelium in the hemostasis mechanism / A.V. Babichev Pediatric. – 2013. – Vol. 4. – № 1. – P. 122–127.

Physiological mechanisms of blood coagulation system / M.A. Khanin, K.V. Thurin. – 2007. – № 3. – P. 71–75.

Effect of different concentrations of red blood cells in whole coagulation link of hemostasis / N.M. Kononenko. – 2008. – Vol. 5. – № 4. – P. 44–45.

Brain regulation of thrombosis and hemostasis : from theory to practice / M.J. Fisher // Basic Science advances for clinicians. – 2013. – Vol. 44. – № 4. – P. 3275–3285.

Aging Hemostasis: Changes to laboratory markers of hemostasis as we age – a narrative Review / E.J. Favoloro, M. Franchini, G. Lippi // Journal of Thrombosis and Haemostasis. – 2014. – Vol. 40. – № 6. – P. 621–633.

Endothelial Von Willebrand factor regulates angiogenesis / R.D. Starke, N.H. Dryden, R.E. Sulton // Blood. – 2011. – Vol. 117. – № 3. – P. 1071–1080.

The basics of diagnostic the hemostasis disorders / Z.S. Barkagan, A.P. Momot. – Moscow : Newdiamed, 1999. – 224 p.

Platelet function beyond hemostasis and thrombosis / J. Ware, A. Corken, R. Khetpal // Current Opinion in Hematology. – 2013. – Vol. 20. – № 5. – P. 448–454.

Diagnosis and controlled therapy of hemostasis disorders / Z.S. Barkagan, A.P. Momot. – Moscow : Newdiamed, 2008. – 292 p.

Molecular interplay between platelets and the vascular wall in thrombosis and hemostasis / A. Berna-Erro, C.P. Redondo, E. Lopez // Current Vascular Pharmacology. – 2013. – Vol. 11. – № 4. – P. 409–430.

Platelets: bridging hemostasis, inflammation and immunity / C. Jenne, R. Urrutia, P. Kubes // International Journal of Laboratory Hematology. – 2013. – Vol. 35. – № 3. – P. 254–261.

The blood coagulation: biochemical basic / M.A. Pantellev, F.I. Ataullahov // Clinical onkohematology. – 2008. – Vol. 1. – № 1. – P. 50–60.

Physiological features of thrombocytes / A.A. Markovchin // Modern problem of science and education. – 2014. – № 6. – P. 1437–1443.

The Role of Act in Platelet Activation / K.A. O’Brien. – Chicago : Illinois Public Media, 2012. – 139 p.

Activators, receptors and ways of intracellular signaling in blood platelets / V.I. Shaturniy, S.S. Shahidjanov, A.N. Sveshnikova // Biomedical chemistry. – 2014. – Vol. 60. – № 2. – P. 182–200.

Platelet protein disulfide isomerase is required for thrombus formation but not for hemostasis in mise / K. Kim, E. Hahm, J. Li // Blood. – 2013. – Vol. 122. – № 6. – P. 1052–1061.

Physiology and pathology of thrombocytes / A.V. Mazurov. – Moscow : Literature, 2011. – 480 p.

Plasma fibronectin supports hemostasis and regulates thrombosis / Y. Wang, A. Reheman, C. Spring // Journal of Clinical investigation. – 2014. – Vol. 124. – № 10. – P. 4281–4293.

Activation of platelet function through G protein-coupled receptors / S. Offermanns // Circulation Research. – 2012. – Vol. 99. – № 12. – P. 1293–1304.

Published

2022-04-26

How to Cite

Савицький, І., Карабут, Л., Савицький, В., & Александріна, Т. (2022). SOME ASPECTS OF THE PATHOGENESIS OF THE HEMOSTASIS SYSTEM. Clinical Anesthesiology and Intensive Care, (2), 52–58. https://doi.org/10.31379/2411.2616.18.2.6