THE NEW BIOMARKERS OF SEVERE SEPSIS AND SEPTIC SHOCK (an analytic review)
Keywords:
severe sepsis, septic shock, biomarkers of sepsisAbstract
Severe sepsis and septic shock are common and often fatal complications in patients who are in critical conditions. At the same time the profound search for adequate and specific biomarkers of sepsis is continuing. T. Lagu et al. (2012) identified a rapid and sustained increase in the incidence of severe sepsis in the United States from 415,280 in 2003 to 711,736 in 2007 (71%). The ratio of patients with severe sepsis and one organ dysfunction decreased from 51% in 2003 to 45% in 2007, where as the patients with 3–4 or more organ dysfunction increased 1.19 times and 1.51 times correspondently. At the same time, there was an annual decrease in hospital mortality by 2% (p<0.001). The authors associate this fact with the strict observance of the diagnostic algorithm and intensive therapy for severe sepsis and septic shock. It was established that markers of endothelial activation are associated with the severity of sepsis, organ dysfunction and mortality in sepsis. The article presents new biomarkers for the diagnostic of severe sepsis and septic shock, assess the severity of disease and the effectiveness of antimicrobial therapy, predicting morbidity and mortality of patients in intensive care units.
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