TREATMENT OF ACUTE VENOUS THROMBOSIS OF LEGS IN ONCOGYNECOLOGY
Keywords:
endometrial cancer, hemostasis system, bemiparin, the risk of trombosisAbstract
Background. The risk of thrombosis in patients with cancer is about 4 times higher than in the population, and this risk increases 6–7 times during a conservative (chemotherapy, hormone- and radiotherapy) and surgical treatment. Aim. Evaluating the effectiveness of the treatment of acute deep venous thrombosis of lower extremities with high doses of low molecular weight heparin Bemiparin. Materials and methods. There was carried out investigation of 30 gynecological patients with endometrial cancer who were prepared for the planned surgical treatment diagnosed with acute venous thrombosis of deep veins of the lower extremities. The diagnosis was confirmed clinically and by means of instrumental methods. In 100% of cases (30 women), all patients were treated with strict bed rest and high doses of bemiparin — 10,000 IU subcutaneously once a day for seven days. The hemostatic system was investigated by coagulation and low-frequency piezoelectric hemoviscosimetry (LFPH). Results. The therapy had positive effect which confirmed clinical and laboratory tests. Indicators LFPH during treatment tend to moderate hypocoagulation. The instrumental study of veins of the lower extremities in 66.66 % of women were found to restore blood flow in the affected vein and almost complete lysis of the clot. In 33.34% of women vein patency with thrombosis improved by 70%. Conclusions. Treatment of patients with deep vein thrombosis of the legs with high doses of bemiparin (10,000 IU for 7 days) has a positive effect which is confirmed by laboratory and clinical tests. In almost 70% of women under study it resulted in clot lysis and blood flow restoration in the affected leg.
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