DIAGNOSIS OF DISORDERS OF THE REGULATION OF BLOOD AGGREGATION IN PATIENTS WITH POLYTRAUMA
Keywords:
polytrauma, trauma-induced coagulopathy, hemostasisAbstract
Background. The problem question about timely diagnosis and correction of the bleeding on the background of trauma-induced coagulopathy in patients with polytrauma is very actual nowadays. The aim of the study was to investigate the functional activity of the regulation of blood coagulation system in patients with polytrauma to determine adequate etiopathogenetical principles of prevention and correction. Materials and methods. The object of the study were patients with diagnosed polytrauma (skeletal trauma, blunt chest trauma, traumatic shock. Clinical material is presented with 60 patients. Age of patients with polytrauma ranged from 21 to 58 years, with a predominance of people of working age (21–49) years — 42 (70%) patients. Blood functional state of patients with polytrauma was determined using instrumental methods — low-frequency pyezoelectric thromboelastography (LPTEG). Differences were considered reliable at p<0.05. Results. All changes in vascular-platelet hemostasis link: decrease in amplitude and intensity of aggregation and increase its time indicate significant (p<0.05) decrease in platelet aggregation in polytrauma patients before treatment. Fibrinolytic activity in patients with polytrauma was significantly increased at 31.42±0.32 16.45±0.40 is norm which is increasing by 91.0%. Conclusions. Revealed abnormalities in the hemostatic system specific to the demonstration trauma-induced coagulopathy in trauma patients: decreasing of aggregation with a significant increase in the activity of fibrinolysis.
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