HEMOSTATIC POTENTIAL IN PATIENTS WITH LIVER CIRRHOSIS
Keywords:
liver cirrhosis, the system of regulation of blood aggregation, hemocoagulation, hemostatic potential, whole blood, global test, low-frequency pezotromboelastographyAbstract
Background. Cirrhosis are epidemiological health problem all over the world with a significant place in the structure of digestive diseases. Goal. To assess the state of the hemostatic potential of whole blood in patients with liver cirrhosis compared with healthy volunteers of Siberian population. Materals and methods. Total — 18 patients (men — 11, women — 7), age: men — 32–62 (48.55) years, women — 42–65 (51.71) years. Group A by Child- Pugh was 6 points, Group B — 8, Group C — 4. The state of hemostasis system was studied on admission before the start of drug therapy drugs that affect blood clotting. As control groups there were taken healthy volunteers from the Siberian population, divided into groups: men aged 21–40 years (n=42), women in menopause (n=38). Results. The study shows that the use of the gelling point (t3) as a sign of stratification in patients with liver cirrhosis allows to distinguish two groups of hemostatic system disorders — “hypocoagulation” and “normal coagulation”. Thus, regardless of the fibrogenesis state, the initial steps of forming cross-linked fibrin are identical in these groups. Conclusions. The use of low frequency pyezothromboelastography global test when assessing the hemostatic potential of whole blood of patients with cirrhosis of the liver to evaluate the depth of disorders of the hemostatic system in all stages of the formation of cross-linked fibrin: initiation, amplification and assembly.
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