ANALYSIS OF CHANGES IN THE INDICES OF HUMORAL IMMUNITY IN PATIENTS WITH AN INCREASED BODY MASS INDEX WITH POLYTRAUMA
DOI:
https://doi.org/10.31379/2411.2616.13.1.8Keywords:
B-lymphocytes, immunoglobulins of classes A, M, G, increased body mass index, polytraumaAbstract
Іmportant is a detailed study of the consistency of actions of various elements and processes of the immune system that occur during different periods of a traumatic disease depending on its severity in victims with an increased body mass index (IВMІ). The purpose of this study was to analyze the changes in the indices of the humoral immunity in patients with IВMІ with polytrauma. In 224 patients with different starting BMI in the period of 1 day – 1 year from the moment of injury, the dynamics of B-lymphocytes, the content of immunoglobulins of classes A, M, G in blood serum were analyzed. The study was conducted on 1, 3, 7, 14, 30 and 360 days from the moment of receiving polytrauma. The obtained data emphasize the importance of humoral reactions in the clinical and pathogenetic aspects of the course of a traumatic disease in patients with IВMІ It was revealed that despite the greater stability of humoral homeostasis compared with cellular resistance to the effects of polytrauma on the body of a patient with IВMІ, its pathogenetic significance in traumatic disease is very important. In turn, the degree of dysfunction of this link of immunity depends on the BMI of each patient.
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