INDUCED DEPRESSION IN A COHORT OF RATS VIA COMMUNICATION
DOI:
https://doi.org/10.31379/2411.2616.12.2.1Keywords:
Infectious depression, rodents, cohabitation sucrose test, open field test, forced-swim testAbstract
More research is required to grasp the phenomenon that is infectious depression entirely. Misunderstandings of this phenomenon stem from lack limited data. There are presently no methods for investigating transmissible depression. Thus, understanding the mechanisms involved in the processes of contagion, preclusion, repression, and treatment remains a mystery. Our aim here was to construct a method of evaluating infectious depression in rats via communication. The induction process for depression consisted of some very stressful activities detailed in the method and material section. Rats were allowed to navigate these activities over five weeks, after which they were tested for depression by their affinity to sucrose. Those rats that showed depressive behaviors were allowed to share a space with healthy ones for a further five weeks in a 1 : 2 ratio. For confirmation of results, we run sucrose test, open field test, and forced swim test at the end of cohabitation. We showed in our experiment how healthy rats became infected after spending a considerable amount of time caged with depressed rats. Likewise, infected rats had a noticeable positive effect on the depressed rats. Given the unusable nature of rats post-trauma after the use of the forced swim test, more in-depth studies may be required for further validation of this procedure.
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