SYSTEMIC INFLAMMATORY RESPONSE OF INFECTIOUS AND NONINFECTIOUS ORIGIN: HEMODYNAMICS AND DAMAGE MARKERS (MULTICENTER RESEARCH)
Keywords:
systemic inflammatory response, cardiac surgery, abdominal sepsis, renal replacement therapyAbstract
Aim. To evaluate changes in hemodynamics, parameters of hydrodynamic status and damage markers in patients with SIRS of infectious and noninfectious etiologies. Materials. 242 patients with abdominal sepsis (n=101) and after cardiac surgeries (n=141) with manifestations of systemic inflammatory response, shock and MOD were included in a prospective multicenter study. Parameters of central hemodynamics (Swan–Ganz catheter), of hydrodynamic status (PiCCO+) were evaluated, damage markers were measured using ELISA (sTREM1, hsCRP, TNF, IL-1, IL-6, IL-8, IL-10). Results. Identical initial data of hemo-, hydrodynamic status and markers have been obtained. Intensive care included 24 hours continuous renal replacement therapy where the tendency to normalization of the main parameters in both groups in case of maintained high values of specific markers of inflammation or cardiac damage has been found. Conclusion. Hemodynamics and hydrodynamic status in patients with SIRS of any origin are rather identical and are accompanied with similar immunoenzyme reactions. Renal replacement therapy, initiated in proper time, prevents the progression of multiple organ dysfunction in patients with systemic inflammatory response, regardless the etiology of the latter.
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